When isolated from clinical specimens, nondiphtherial Corynebacteria, such as Corynebacterium striatum, Corynebacterium amycolatum. ABSTRACT. We describe an unusual cluster of Corynebacterium striatum infections in 21 patients with chronic obstructive pulmonary disease (COPD) admitted. Objective: To evaluate the clinical significance of and describe factors associated with Corynebacterium striatum infection. Methods: A.
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This is an open access article distributed under the Creative Commons Attribution Licensewhich permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. A year-old woman visited our emergency department because of striattum dyspnea due to severe left ventricular functional failure. It progressed to disseminated intravascular coagulation and disturbance of consciousness on day 67 of admission.
Gram-positive bacilli were detected from two different blood culture samples on day 67 of admission. The bacterium was detected from the removed central venous catheter tip too, and the patient was diagnosed with catheter-related bloodstream infection by C. corynebaterium
However, treatment was not effective, and the patient died on day 73 of admission. The Corynebacteria are a group of aerobic, Gram-positive, catalase-positive, nonsporulating, generally nonmotile rods [ 1 ]. The Corynebacteria are divided into two groups: Corynebacterium diphtheriae and nondiphtherial Corynebacteriacollectively referred to as diphtheroids. When isolated from clinical specimens, nondiphtherial Corynebacteriasuch as Corynebacterium striatumCorynebacterium amycolatumCorynebacterium minutissimumCorynebacterium xerosisand Corynebacterium freneyiwere originally thought to be contaminants [ 2 ], as these strains are commonly considered as part of the normal flora of human skin and corynebacteium membranes.
However, in corynebacteium years, they have been reported as emerging opportunistic pathogens in immunocompromised patients with end-stage cancer, hematologic malignancy, and critical condition [ 2 ]. There are several striaum of C. In the present case, we report a catheter-related bloodstream infection caused by C.
A year-old woman was brought to our emergency department because of xorynebacterium dyspnea due to severe left ventricular functional failure. Her vital signs were unstable; corynenacterium, she was immediately admitted to the intensive care unit ICU. She had two comorbidities: Although an implantable cardioverter defibrillator CRT-D, Cardiac Resynchronization Therapy-Defibrillationwith biventricular pacing function, was replaced with PM for severe left ventricular functional decline, on day 12 of admission, an intra-aortic balloon pump IABP was also inserted because of multiple organ failure.
The IABP was removed on day 16 of admission.
Thereafter, there was no obvious fever, signs of infection, so no antibiotics were administered. However, intermittent hemodialysis was stritaum due to liver failure and renal failure, and an IABP was necessary again after a worsening of cardiac function on day The illness progressed to disseminated intravascular coagulation DIC and disturbance of consciousness on day 67 of admission.
Therefore, two sets of blood samples for blood culture were collected. Gram-positive bacilli were detected in both blood culture samples; each set included aerobic and anaerobic cultures Figures 1 b and 1 c.
No corynebacterrium species could be identified at this time.
Some asynergy in wall motion was detected by echocardiography, but no vegetation was seen. Striatuj this time, another two sets of blood samples were collected and blood cultures were negative. However, the patient died on day 73 of admission.
Case Reports in Infectious Diseases
This method is based on the assessment of biochemical properties. The bacterium was detected from the removed central venous catheter tip too. Thus, the patient was diagnosed with a C. The majority of cases of C. However, most of these cases are represented by patients corynnebacterium implanted indwelling devices or who present an immunosuppression [ 26 ]. Because her general condition worsened, implanted indwelling devices as central venous catheter might cause bacteremia by C.
To our knowledge, this is the second report which found both blood cultures and cultures from a central venous catheter tip positive for the same strain of C. Outbreaks caused by multidrug-resistant C. Although patients with implanted CRT-D may develop infectious endocarditis, obvious vegetation was never observed on echocardiography in these cases [ 11 ].
In addition, there is a report of a stratum who underwent hemodialysis and developed sepsis caused by a Corynebacterium sp. As the same type of bacteria was detected by the catheter tip culture, the cervical catheter was withdrawn during the hemodialysis, as it was presumed to be the port of entry in this case.
Corynebacterium striatum Bacteremia Associated with a Catheter-Related Blood Stream Infection
Although the biochemical properties of C. However, this compound can only be detected by special analyses, for example, gas chromatography; thus C. Since most of reports classified C. This would eventually lead this strain to become corynsbacterium secondary colonizer in immunocompromised hosts [ 8 ]. In a previous report, vancomycin was recommended as empirical therapy for serious infections caused by Corynebacterium spp.
Therefore, in this case, appropriate antibiotics could not be judged in vivo. However, the optimal antimicrobial therapy for these infections is still controversial.
In vitro susceptibility tests showed that linezolid and tigecycline are active against coryneform bacteria, revealing a potential therapeutic value [ 1516 ] of these compounds. Currently, there are no guidelines for the treatment of Corynebacterium spp.
Appropriate susceptibility tests and interpretive criteria are critically needed, in light of the growing emergence of multidrug resistance and its involvement in nosocomial infections. In conclusion, although Corynebacterium could be isolated from a sstriatum culture as a common contaminant, in certain case this observation could conceal a dangerous infection.
Patients with a history of exposure to broad-spectrum antibiotics or immunosuppression, as well as critically ill patients with an implanted indwelling device or a central venous catheter, must be considered at high risk of severe infection for this type of bacteria and it is necessary to recognize C.
Corynebacterium striatum: a diphtheroid with pathogenic potential.
In conclusion, we encountered a case of catheter-related bloodstream infection caused by C. Unfortunately, we could not successfully treat the patient because of her poor general condition and comorbidity. Case Reports in Infectious Diseases. Indexed in Web of Science. Subscribe to Table of Contents Alerts. Table of Contents Alerts. Abstract A year-old woman visited our emergency department because of exertional dyspnea due to severe left ventricular functional failure.
Introduction The Corynebacteria are a group of aerobic, Gram-positive, catalase-positive, nonsporulating, generally nonmotile rods [ 1 ].
Case Presentation A year-old woman corynegacterium brought to our emergency department because corrynebacterium exertional dyspnea due to severe left ventricular functional failure. Minimum Inhibitory Concentration of the C. View at Google Scholar A.