Cuerpos de Weibel-Palade. Quite the same Wikipedia. Just better. the. Weibel-. Palade bodies can be released from cultured endothebial cells upon exposure to nonphysiobogic secretagogues such as the calcium ionophore . Pulmonary epithelioid hemangioendothelioma. Weibel-Palade bodies. CD Palabras clave: Hemangioendotelioma epitelioide. Cuerpos de Weibel-Palade.
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Weibel-Palade bodies: a window to von Willebrand disease.
Weibel—Palade bodies are the storage granules of endothelial cellsthe cells that form the inner lining of the blood vessels and heart. They store and release two principal molecules, von Willebrand factor and P-selectinand thus play a dual role in hemostasis and inflammation. Weibel—Palade bodies were initially described by the Swiss anatomist Ewald R.
Weibel wfibel the Romanian physiologist George Emil Palade in There are two major components stored within Weibel—Palade bodies. One is von Willebrand factor vWFa multimeric protein that plays a major role in blood coagulation.
Immature Weibel—Palade bodies cuepros near the nucleus, where they acquire more membrane proteins and then disperse throughout the cytoplasm, carried along microtubules by kinesins. Maturing Weibel—Palade bodies may also fuse with each other. The only parallel organelle in physiology is the alpha granule of plateletswhich also contains vWF. The small subset of Weibel—Palade bodies tethered weiel the cell periphery to the actin cortex serve as a readily releasable pool that’s replenished by a larger pool of microtubule-associated bodies in the cell interior.
The contents of Weibel—Palade bodies are secreted by one of three mechanisms. IL-8, CD63 to diffuse out. As Weibel—Palade bodies fuse with secretory pods, their vWF cargo loses its tubular form for spaghetti-like strings that are then exocytosed through a fusion pore.
Different modes of cargo release from Weibel—Palade bodies may be a mechanism for differential release of subsets of molecules in different physiological conditions. The importance of Weibel—Palade bodies are highlighted by some human disease mutations.
Mutations within vWF are the usual cause of the most common inherited bleeding disorder, von Willebrand disease.
From Wikipedia, the free encyclopedia.
Weibel–Palade body – Wikipedia